Alkaloids from cryptocarya densiflora blume (lauraceae) and their cholinesterase inhibitory activity (IR)

Wan Othman Wan Nurul Nazneem, Sivasothy Yasodha, Liew Sook Yee, Mohamad Jamaludin, Nafiah Mohd Azlan, Ahmad Kartini, Litaudon Marc,

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Type :	article
Subject :	Q Science (General)
ISSN :	1874-3900
Main Author :	Wan Othman Wan Nurul Nazneem, Sivasothy Yasodha, Liew Sook Yee, Mohamad Jamaludin, Nafiah Mohd Azlan, Ahmad Kartini, Litaudon Marc,
Title :	Alkaloids from cryptocarya densiflora blume (lauraceae) and their cholinesterase inhibitory activity (IR)

Year of Publication :	2017
PDF Full Text :	The author has requested the full text of this item to be restricted.

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(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-Nmethyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.

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